Nasal in-situ gel of Zolmitriptan was prepared for sustained release and improvement of drug bioavailability. Carbopol 934 was used as a key ingredient which gives pH-induced sol to gel conversion of the formulations. Different formulations were prepared by varying the concentrations of Carbopol 934 and HPMC K4M. These formulations were evaluated for parameters like drug excipient compatibility, pH, drug content, viscosity, gel strength, mucoadhesive strength, in vitro drug release and Histopathological study. A 32 factorial was applied to check the effect of varying the concentration of carbopol 934 (X1) and different grades of HPMC K4M (X2) on the dependent variable i.e. viscosity, gel strength, mucoadhesive strength, % drug released at 0.25 hr, % drug released at 1 hr and % drug released at 8 hr as dependent variables . In vitro release data was fitted to various models to ascertain the kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F-statistics were used to select the most appropriate model. Formulation F5 was considered optimized formulation of in-situ nasal gel of Zolmitriptan. The studies indicate that the formulation was effective in providing in-vitro permeation of drug and the mucoadhesion which increases the residence time of drug.
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